Une approche pour regrouper des sujets atteints de cancers, sur la base des similarités des répartitions cellulaires au sein de leurs biopsies
Abstract
We introduce an interpretable methodology to cluster subjects suffering from cancer, based
on features extracted from their biopsies. We capture patterns in cell distributions using histograms,
and compare subjects based on these. We describe here a workflow to define these
histograms and use them for clustering purposes. We illustrate our approach on a database of
hematoxylin and eosin-stained tissues of subjects with Stage I lung adenocarcinoma, where
our results match existing knowledge with high confidence.